First human CRISPR study in the US could begin soon

The study will collect up to 18 patients with multiple myeloma, melanoma and/or two types of sarcoma. Penn scientists will use CRISPR to delete two particular genes in patients’ T cells: The first, PD-1, can be manipulated by cancer cells to impede the immune system, while the second is an alarm-sounding receptor that will be …

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